Weight-loss jabs for obese kids ‘are effective and help prevent mealtime rows’

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Summary

The National Institute for Health and Care Excellence (Nice) previously stopped its appraisal of semaglutide (Wegovy) for use in 12 to 17-year-olds after the manufacturer, Novo Nordisk, said it was unable to provide evidence for submission.

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Q1: What is the current understanding of the effectiveness of exercise as an intervention for weight loss in obese children and adolescents?

A1: Exercise is recognized as a key component in managing obesity among children and adolescents. Recent research and guidelines, including those from the American Academy of Pediatrics in 2023, emphasize increased physical activity as a mainstay of obesity therapy. Exercise not only contributes to weight loss but also improves insulin resistance and reduces the risk of metabolic diseases. However, the success of exercise-based interventions is influenced by environmental factors, mental health, and societal attitudes. Combining exercise with nutritional and behavioral strategies yields the best outcomes for weight management in young people.

Q2: How does the living environment impact physical activity levels and weight loss outcomes in children and adolescents?

A2: Studies have shown that the local environment plays a significant role in determining the physical activity levels of children and adolescents. Research from the BigO project demonstrated that urban environment characteristics can predict population behavior regarding physical activity with up to 81% accuracy. Factors such as access to parks, walkability, and neighborhood safety directly influence children's opportunities to exercise, which in turn affects obesity rates and weight loss outcomes.

Q3: What are the latest scholarly findings on the use of exercise in managing obesity among adolescent females?

A3: A recent review published in 2025 highlights that lifestyle changes, particularly increased exercise and reduced calorie intake, remain central to managing obesity among adolescent females. This approach helps decrease insulin resistance and associated metabolic diseases. However, the review also notes the high prevalence of mental health and sleep disorders in this group, suggesting that addressing these issues is vital for improving overall health and supporting successful lifestyle changes.

Q4: What is the relationship between exercise, diet, and obesity as discussed in social media research?

A4: A large-scale study analyzing over 4.5 million Twitter posts found that public discussions frequently link exercise, diet, and obesity. Of the tweets examined, 16.6% discussed exercise and 51.7% focused on obesity, with a strong correlation between the two topics. Other related themes included mental health, brain health, and daily fitness routines, indicating that public perception recognizes the interconnectedness of these factors in weight loss and health.

Q5: What are some motivational facts regarding strength training and its benefits for weight loss in youth?

A5: Strength training, encompassing activities like weight lifting, bodyweight exercises, and plyometrics, is not only effective for increasing muscle and bone strength but also boosts metabolism and reduces injury risk. For young people, regular strength training can enhance joint function and cardiac health, making it a powerful addition to any weight loss and fitness program.

Q6: What are the challenges and considerations in recommending weight loss exercise programs to obese children and adolescents?

A6: While exercise is beneficial, challenges include environmental barriers, obesity stigma, and the risk of disordered eating. Mental health and sleep disorders are prevalent among obese youth, and these must be addressed for interventions to succeed. Additionally, provider encouragement must be balanced with sensitivity to avoid triggering negative psychological responses. Comprehensive programs that integrate mental health support, family involvement, and tailored exercise plans are most effective.

Q7: Are there emerging alternatives or complements to exercise for managing obesity in young people, based on recent research?

A7: Recent advances include the early use of weight loss medications, such as glucagon-like peptide-1 receptor agonists, particularly for adolescents with severe obesity. Bariatric surgery is also an option in some cases, showing promising short- and medium-term outcomes. Natural products like berberine are being investigated for their anti-obesity effects, though challenges with absorption and bioavailability remain. These approaches are considered adjuncts and not replacements for exercise and lifestyle modifications.

References:

  • Weight loss (Wikipedia) https://en.wikipedia.org/wiki/Weight_loss
  • Strength training (Wikipedia) https://en.wikipedia.org/wiki/Strength_training
  • Obesity Management in Female Adolescents. © 2025 John Wiley & Sons Ltd.