Examining EKGs in Foundational Models for Cardio-Oncology – CancerNetwork

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Summary

In a conversation with CancerNetwork, Arturo Loaiza-Bonilla, MD, MSEd, FACP, the systemwide chief of Hematology and Oncology at Saint Lukes University, discussed the application of electrocardiograms (EKGs) in foundational models to help facilitate cardio-oncology processes.

First, he highlighted…

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Q1: What are the potential benefits of using electrocardiograms (EKGs) in the field of cardio-oncology?

A1: Electrocardiograms (EKGs) are utilized in cardio-oncology to detect and monitor cardiovascular changes that occur during cancer treatment. EKGs serve as a non-invasive tool to identify cardiotoxic effects of cancer therapies such as chemotherapy and immunotherapy. This allows for early intervention and management of potential cardiac complications, thereby improving patient outcomes.

Q2: How is artificial intelligence (AI) being integrated into EKG analysis for cardio-oncology?

A2: AI is being integrated into EKG analysis in cardio-oncology to enhance the detection and prediction of cardiovascular complications. AI models analyze EKG data alongside demographics, comorbidities, and lab tests to predict adverse cardiovascular events in cancer patients. The use of AI in this context can improve the accuracy of risk stratification and guide treatment decisions.

Q3: What did recent studies reveal about the use of machine learning with EKG data in diagnosing neoplasms?

A3: Recent studies have demonstrated that machine learning models using EKG data can effectively diagnose neoplasms by detecting cardiovascular changes associated with these conditions. These models achieve high diagnostic accuracy and are particularly beneficial in resource-limited settings due to their cost-effectiveness and scalability.

Q4: What role does the European Society of Cardiology play in the field of cardio-oncology?

A4: The European Society of Cardiology has been actively involved in advancing cardio-oncology by establishing guidelines and collaborations with other organizations. They focus on prevention, diagnosis, and management of cardiotoxicity induced by cancer treatments, emphasizing cardiovascular risk assessment and regular monitoring of cancer patients.

Q5: How does high fructose consumption affect cardiotoxicity in cancer patients treated with 5-Fluorouracil?

A5: High fructose consumption may exacerbate cardiotoxicity in cancer patients treated with 5-Fluorouracil (5-FU). This is due to the pathophysiological mechanisms such as inflammation and oxidative stress induced by high fructose intake, which can increase the adverse cardiac effects of 5-FU treatment.

Q6: What advancements have been made in using cardiac magnetic resonance imaging (CMR) in cardio-oncology?

A6: Advancements in cardio-oncology using cardiac magnetic resonance imaging (CMR) include the development of deep learning frameworks to identify clonal hematopoiesis of indeterminate potential (CHIP), which is associated with adverse cardiovascular outcomes. These models help predict future cardiomyopathy, offering a non-invasive screening tool for risk stratification and personalized treatment.

Q7: What are the challenges in integrating AI into clinical workflows in cardio-oncology?

A7: Challenges in integrating AI into clinical workflows in cardio-oncology include the limited availability of large datasets for model training, insufficient external validation of AI tools, and difficulties in incorporating AI seamlessly into routine clinical practice. Addressing these challenges requires advancements in AI technology, robust validation, and a multidisciplinary approach.

References:

  • Examining EKGs in Foundational Models for Cardio-Oncology - CancerNetwork
  • Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study
  • Assessment of Clonal Hematopoiesis of Indeterminate Potential and Future Cardiomyopathy from Cardiac Magnetic Resonance Imaging using Deep Learning in a Cardio-oncology Population
  • Prevention of Chemotherapy-Induced Cardiotoxicity: The Role of the ECG
  • High Fructose Consumption May Increase 5-Fluorouracil - Induced Cardiotoxicity
  • Cardio-oncology
  • Building AI-ECG models for predicting cardiovascular outcomes in cancer patients